Review





Similar Products

stemmacs ipsc brew xf medium  (Miltenyi Biotec)
95
Miltenyi Biotec stemmacs ipsc brew xf medium
Stemmacs Ipsc Brew Xf Medium, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/stemmacs ipsc brew xf medium/product/Miltenyi Biotec
Average 95 stars, based on 1 article reviews
stemmacs ipsc brew xf medium - by Bioz Stars, 2026-02
95/100 stars
  Buy from Supplier
hpsc derived cardiomyocyte isolation kit  (Miltenyi Biotec)
96
Miltenyi Biotec hpsc derived cardiomyocyte isolation kit
Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human <t>cardiomyocyte</t> (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).
Hpsc Derived Cardiomyocyte Isolation Kit, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/hpsc derived cardiomyocyte isolation kit/product/Miltenyi Biotec
Average 96 stars, based on 1 article reviews
hpsc derived cardiomyocyte isolation kit - by Bioz Stars, 2026-02
96/100 stars
  Buy from Supplier
selection kit  (Miltenyi Biotec)
96
Miltenyi Biotec selection kit
Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human <t>cardiomyocyte</t> (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).
Selection Kit, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/selection kit/product/Miltenyi Biotec
Average 96 stars, based on 1 article reviews
selection kit - by Bioz Stars, 2026-02
96/100 stars
  Buy from Supplier
hpsc derived cardiomyocyte isolation kit miltenyi biotec  (Miltenyi Biotec)
96
Miltenyi Biotec hpsc derived cardiomyocyte isolation kit miltenyi biotec
Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human <t>cardiomyocyte</t> (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).
Hpsc Derived Cardiomyocyte Isolation Kit Miltenyi Biotec, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/hpsc derived cardiomyocyte isolation kit miltenyi biotec/product/Miltenyi Biotec
Average 96 stars, based on 1 article reviews
hpsc derived cardiomyocyte isolation kit miltenyi biotec - by Bioz Stars, 2026-02
96/100 stars
  Buy from Supplier
stemmacs psc support xf  (Miltenyi Biotec)
94
Miltenyi Biotec stemmacs psc support xf
Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human <t>cardiomyocyte</t> (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).
Stemmacs Psc Support Xf, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/stemmacs psc support xf/product/Miltenyi Biotec
Average 94 stars, based on 1 article reviews
stemmacs psc support xf - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier
stemmacs psc brew xf medium  (Miltenyi Biotec)
95
Miltenyi Biotec stemmacs psc brew xf medium
Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human <t>cardiomyocyte</t> (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).
Stemmacs Psc Brew Xf Medium, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/stemmacs psc brew xf medium/product/Miltenyi Biotec
Average 95 stars, based on 1 article reviews
stemmacs psc brew xf medium - by Bioz Stars, 2026-02
95/100 stars
  Buy from Supplier
psc derived cardiomyocyte isolation kit  (Miltenyi Biotec)
96
Miltenyi Biotec psc derived cardiomyocyte isolation kit
Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human <t>cardiomyocyte</t> (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).
Psc Derived Cardiomyocyte Isolation Kit, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/psc derived cardiomyocyte isolation kit/product/Miltenyi Biotec
Average 96 stars, based on 1 article reviews
psc derived cardiomyocyte isolation kit - by Bioz Stars, 2026-02
96/100 stars
  Buy from Supplier

Image Search Results


Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human cardiomyocyte (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).

Journal: Cell Reports Medicine

Article Title: A combined genomic arrhythmia propensity score delineates cumulative risk

doi: 10.1016/j.xcrm.2025.102455

Figure Lengend Snippet: Ultrarare noncoding variants enhance arrhythmia risk (A) Noncoding regulatory regions of CMAR and epilepsy genes were identified by overlaying ATAC sequencing and Hi-C data from the heart and brain. Variants within these regions were analyzed. (B) Ultrarare variants (defined as not observed in gnomAD and a combined cohort AF <0.01) were enriched in cases compared to controls (permutation test, ∗∗∗∗ p < 1e−4, mean per individual ±SEM). (C) Enrichment of ultrarare regulatory variant target genes in cases compared to controls, with probability of loss of function intolerance (pLI). y axis is −log10 p value (χ2 test, Bonferroni corrected). Color is the ratio of variants per mapped gene (dots indicate genes with p < 0.05). (D) Motif enrichment in the 20-bp surrounding ultra-rare variants in cases. (E) Example noncoding regions with ultrarare case variants in transcription factor-binding motifs. Tracks shown in hg38 with human cardiomyocyte (CM) ATAC-seq tracks (top) and engineered heart tissue ATAC-seq tracks (below). Hi-C promoter contacts with ATAC-seq peaks also shown. Regulatory elements highlighted in yellow and promoters in pink. Within each peak sits a variant predicted to alter transcription factor binding. Motif and base pair change shown below in blue. (F) Regulatory variant score boxplots within-cohort. Scores derived from a linear model that incorporates ultrarare and rare (gnomAD AF<0.001) variants in the regulatory intervals (Wilcoxon rank-sum test, boxplot: median, IQR, and 1.5 IQR). (G) Log2 OR of being a case is shown across the regulatory variant score quintiles within-cohort (# indicates an OR 95% CI lower bound ≥1; dashed line indicating the null hypothesis, OR = 1, and untransformed ORs to the right.).

Article Snippet: hPSC-Derived Cardiomyocyte Isolation Kit , Miltenyi Biotec , cat# 130-110-188.

Techniques: Sequencing, Hi-C, Variant Assay, Binding Assay, Derivative Assay